Health Economics and Payer Evidence Director – Cambridge, UK


The Health Economics & Payer Evidence Director (HEPED) is a senior-level global role that leads the generation of payer evidence data and material. This contains leading the development of the core global payer evidence deliverables including the production of the Global Reimbursement Dossier (GRD), health economic models, literature reviews, indirect treatment comparisons, as well as input into patient-reported outcomes (PROs) and real-world evidence (RWE). The HEPED will ensure that payer needs are embedded in the target product profile and clinical programs. To do this, the HEPED can, as needed by the business, serve as the representative for the payer perspective on the Global Product Team (GPT), nurturing payer requirements and incorporating evidence needs within product development strategies, and work in collaboration with the Global Pricing and Market Access team.

The HEPED will also demonstrate scientific leadership, including development of publication plans, engagement with key external experts, and disseminate the work externally with a strong scientific foundation. The HEPED has an in-depth, expert knowledge of both health economics and payer evidence, and its strategic application to pharmaceutical development throughout the development process and subsequent market access. In addition to having global launch experience, the holder will also be a highly effective communicator and influencer, as well as showing business acumen and effective prioritisation and focus.

Tezepelumab is developed in severe asthma as the first indication with submissions planned in the first half of 2021, followed by atopic dermatitis, nasal polyps, and further indications for which submissions are anticipated for 2023 onwards.


  • Develop a payer evidence plan at each investment decision and provide payer evidence requirements into the Clinical Development Plan, ensuring its implementation/delivery and communication
  • Deliver, customer-focused and robust Global Reimbursement Dossiers (GRDs)
  • Support the key markets in their payer submissions, responses, and any additional analyses
  • Represent the payer perspective on the labelling and regulatory activities team
  • Detailed and planning of payer analytics to support market access and reimbursement for assigned projects.
  • Drive the publication policy to support payer needs, generate peer-reviewed scientific publications, as well as effective communication of sophisticated ideas for use with both payers and other partners.
  • Participate in external health economics, payer evidence and analytic departmental activities via technical presentations, committee membership, publication reviews, and other similar activities
  • Actively supervise and apply new analytical techniques and payer evidence trends
  • Interact with health technology appraisal authorities and advisors/key external experts in preparing materials for scientific advice and reimbursement submissions
  • Mentor and develop colleagues including, as the need arises by the business, indirect line management


Education and training

  • Graduate / College degree in biomedical science, business, quantitative subject areas or economics.
  • Formal post graduate degree in health economics or a related subject area, or substantial work experience in the field.
  • PhD in relevant field (e.g. health economics, health policy, outcomes research, health services research, epidemiology) or MD (with significant experience in these areas) (desirable).


  • Payer, HTA, public health, or health policy experience (desirable).
  • Payer launch experience at a global level.
  • A track record of delivery in the payer area, in terms of strategy development, health economic models, evidence generation, or in influencing payer decision making.
  • Several years of project leadership experience in the generation of health economic and payer evidence or development and execution of payer strategies.
  • In-depth knowledge of international healthcare systems and their changing needs for health economic and payer evidence.
  • Track record of external influencing, including public speaking and publications in high-quality journals on topics relevant to evidence exploration to advance the interests of the business.
  • Outstanding evidence generation and analytic skills to craft and deliver P&MA strategies (e.g. including trial design, RWE, PROs, health economic modelling, and evidence synthesis)
  • Evidence of generating novel solutions to sophisticated, cross-geographical, or cross-functional challenges.
  • Drives the implementation of these solutions, taking calculated risks to reach the right outcome for the business.


  • Ability to anticipate future external payer environment requirements, thinking broadly across multiple geographies
  • Setting the strategic direction for the evidence generation based on an ability to think broadly
  • Leadership skills and problem-solving capability as demonstrated by evaluate threats and opportunities for payers and plan for appropriate access strategies
  • Prioritization and impactful communication skills, including the ability to effectively challenge conceptual thinking as vital, influence other functions, and communicating sophisticated issues appropriately for the audience.
  • Expertise on diverse evidence methodologies and analyses (including analytic techniques and tools such as input into clinical trial design and analyses, systematic literature reviews, comparative effectiveness and economic modelling) and their cross-function implications at the portfolio level.
  • Empowers other functions to support the delivery of payer strategy, anticipating and removing obstacles to their delivery.
  • Develops and uses internal and external networks, including leading academic and information bodies, to craft future trends to ensure that the most up-to-date analytical techniques are being applied to improve payer leverage.

At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. We’re focused on the potential of science to address the unmet needs of patients around the world. We commit to those areas where we think we can really change the course of medicine and bring big new ideas to life. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.



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